Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter

doi:10.1016/0896-6273(92)90172-A

Neuron

Volume 9, Issue 2, August 1992, Pages 337-348

https://doi.org/10.1016/0896-6273(92)90172-A Get rights and content

Abstract

The synaptic action of γ-aminobutyric acid (GABA) is terminated by high affinity, Na⁺-dependent transport processes in both neurons and glia. We have isolated a novel GABA transporter cDNA, GAT-B, which encodes a high affinity (K_m = 2.3 μM), Na⁺- and Cl⁻-dependent GABA transport protein that is potently blocked by β-alanine, a compound generally considered a selective inhibitor of glial transport. However, in situ hybridization studies indicate that GAT-B mRNA is expressed predominantly within neurons. These data indicate that the neuronal-glial distinction of GABA transporters based on inhibitor sensitivities must be reconsidered and suggest a greater diversity of GABA transporters than has been predicted by previous pharmacologic studies.

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Neuron

ArticleFunctional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter

Abstract

Brain Res.

Anal. Biochem.

Brain Res.

Brain Res.

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Dev. Brain Res.

J. Biol. Chem.

High affinity uptake of γ-aminobutyric acid in cultured glial and neuronal cells

Neurochem. Res.

Deficits in small interneurons in prefrontal and cingulate cortex of schizophrenic and schizoaffective patients

Arch. Gen. Psychiatry

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J. Neurosci.

Cloning and expression of a functional serotonin transporter from rat brain

Nature

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J. Neurochem.

A carrier for GABA uptake exists on noradrenaline nerve endings in selective rat brain areas but not on serotonin terminals

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Article
Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter