European Journal of Pharmacology: Molecular Pharmacology
Regulation of histamine H1 receptor-mediated phosphoinositide hydrolysis by histamine and phorbol esters in DDT1 MF-2 cells
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Cited by (13)
Investigation on signal transduction pathways after H <inf>1</inf> receptor activated by histamine in C6 glioma cells: Involvement of phosphatidylinositol and arachidonic acid metabolisms
2012, Journal of the Chinese Medical AssociationCitation Excerpt :Histamine-induced IP1 accumulation in C6 glioma cells with an EC50 of 4.2 μM caused more than an 11-fold increase over the basal level at maximal response of 100 μM histamine. The EC50 value obtained in this study is comparable with that of related glial cells and other cells used in the previous studies, such as U373 MG astrocytoma (EC50 = 5.4 μM),24 DDT1 MF-2 (EC50 = 10 μM),25 astrocyte-enriched primary culture (EC50 = 1.7 μM),13 oligodendroglioma (EC50 = 1.6 μM),26 and C6 glioma cells (EC50 = 24 μM5). Histamine-induced transient [Ca2+]i increase, with an EC50 of 4.9 μM, was higher than its sustained [Ca2+]i increase, with EC50 of 0.63 μM.
Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells
1996, Biochemical PharmacologyMolecular pharmacological aspects of histamine receptors
1995, Pharmacology and TherapeuticsEvidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization
1991, European Journal of PharmacologyProtocols for regulation and study of diphosphoinositol polyphosphates
2004, Molecular PharmacologyRegulation of the human histamine H<inf>1</inf> receptor stably expressed in Chinese hamster ovary cells
1996, British Journal of Pharmacology
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