European Journal of Pharmacology: Molecular Pharmacology
Polyamine and ifenprodil interactions with the NMDA receptor's glycine site
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Cited by (30)
The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research
2019, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Several endogenous compounds including polyamines and other biogenic amines have been identified that do not act as agonists but as positive modulators, which can bind to the NMDA receptor and produce a maximal enhancement in its response or increased affinity of agonist (Ogden and Traynelis, 2011). In addition, polyamines by two manners modulate NMDA receptor complex: in voltage-dependent manner polyamines act inside the NMDA receptor channel but in voltage-independent manner they at the extracellular modulatory site directly modulate interactions of glycine with the NMDA receptor complex or by glycine-independent mechanism enhance NMDA receptor responses (Ransom, 1991; Ransom and Deschenes, 1990; Williams, 1997). The endogenous polyamines spermine and spermidine and the Mg2+ ion are other PAMs compound that have been known to bind to modulatory site on the NTDs of GluN2B receptors (Zhu and Paoletti, 2015).
Treating metastatic castration-resistant prostate cancer with novel polyamine-free oral nutritional supplementation: Phase I study
2013, BioMedicine (Netherlands)Citation Excerpt :Rapid pain control was most likely not due to tumor control, because progressive cases also exhibited pain improvement. It possibly relates to the fact that PAs are known to regulate N-methyl-d-aspartate (NMDA) receptors and, in particular, their NR2B subunit, which is involved in pain perception [12–15]. This NMDA receptor is widely expressed in the nervous system and has been implicated in a variety of synaptic signaling events that also modulate other functions: for example, learning, memory processing, and feeding.
Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients
2010, Biomedicine and PharmacotherapyAnticonvulsant effects by combined treatment with a glycine, receptor antagonist and a polyamine site antagonist in amygdala-kindled rats
1997, European Journal of Pharmacology