European Journal of Pharmacology: Molecular Pharmacology
Rapid communicationSensitivity of AMPA receptors to pentobarbital
References (8)
- et al.
Argiotoxin detects molecular differences in AMPA receptor channels
Neuron
(1993) - et al.
Use-dependent pentobarbital block of kainate and quisqualate currents
Brain Res.
(1993) - et al.
Voltage-dependent block of excitatory amino acid currents by pentobarbital
Brain Res.
(1986) - et al.
Mehohexitone antagonises kainate and epileptiform activity in rat neocortical slices
Eur. J. Pharmacol.
(1992)
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The mechanisms of Zn<sup>2+</sup> effects on Ca<sup>2+</sup>-permeable AMPA receptors on carp retinal horizontal cells
2010, Brain ResearchCitation Excerpt :Furthermore, the contribution of extracellular Ca2+ to the Zn2+ effects was also tested. In order to examine the glutamate current mediated by CP-AMPARs, pentobarbital (PB) of 100 µM, a selective blocker of CP-AMPAR, was applied in all the experiments (Taverna et al., 1994; Yamakura et al., 1995; Van Damme et al., 2002; Sun et al., 2010). A typical experimental recording showing the Zn2+ potentiation effect in the presence of 20 µM CTZ is plotted in Fig. 1B.
Synaptic contribution of Ca<sup>2+</sup>-permeable and Ca<sup>2+</sup>-impermeable AMPA receptors on isolated carp retinal horizontal cells and their modulation by Zn<sup>2+</sup>
2010, Brain ResearchCitation Excerpt :From the results given in Fig. 2A and C, it is clearly shown that the NAS-insensitive glutamate-current mediated by CIP-AMPARs contributed a small proportion to the whole glutamate-response. Pentobarbital (PB), which selectively suppresses CIP-AMPAR at a concentration of 100 μM (Taverna et al., 1994; Yamakura et al., 1995; Van Damme et al., 2002), was also applied to directly examine the synaptic contribution of CIP-AMPARs to the cell's glutamate-response. An example is given in Fig. 3A.
Characterization of ionotropic glutamate receptors in insect neuro-muscular junction
2009, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyAdaptation to synaptic inactivity in hippocampal neurons
2005, NeuronCitation Excerpt :In contrast, little is known about the molecular and functional changes that result from prolonged inactivity of synapses, as may arise with sensory impairment, stroke, and other forms of neural damage. AMPAR antagonism is of particular interest because it is a known effect of several anesthetics (Taverna et al., 1994, Harris et al., 1995) and anticonvulsants (Perucca, 1997, De Sarro et al., 2005) and has been proposed for treatment of Parkinson’s disease (Johnston and Brotchie, 2004), ALS, and several other neurological disorders (Parsons et al., 1998). Understanding the mechanisms underlying the response to prolonged inactivity has been confounded by the diversity of previously reported changes.