Review
Anandamide, an endogenous cannabinomimetic eicosanoid: ‘Killing two birds with one stone’

https://doi.org/10.1016/0952-3278(95)90077-2Get rights and content

First page preview

First page preview
Click to open first page preview

References (65)

  • W Van der Kloot

    Anandamide, a naturally occurring agonist of the cannabinoid receptor, blocks adenylate cyclase at the frog neuromuscular junction

    Brain Res

    (1994)
  • AP Wickens et al.

    Δ9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats

    Eur J Pharmacol

    (1993)
  • R Pertwee et al.

    Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia

    Eur J Pharmacol

    (1994)
  • DE Epps et al.

    The alteration of rabbit skeletal sarcoplasmic reticulum function by N-acylethanolamine, a lipid associated with myocardial infarction

    Cell Calcium

    (1982)
  • NM Gulaya et al.

    The effect of long-chain N-acylethanolamines on some membrane-associated functions of neuroblastoma C1300 N18 cells

    Biochim Biophys Acta

    (1993)
  • NR Bachur et al.

    Microsomal synthesis of fatty acid amides

    J Biol Chem

    (1966)
  • NR Bachur

    Synthesis of fatty acid amides

    Methods Enzymol

    (1969)
  • V Natarajan et al.

    On the biosynthesis and metabolism of N-acylethanolamine phospholipids in infarcted dog heart

    Biochim Biophys Acta

    (1981)
  • PC Schmid et al.

    Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type

    J Biol Chem

    (1983)
  • DG Deutsch et al.

    Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

    Biochem Pharmacol

    (1993)
  • KK Kruszka et al.

    The ATP- and CoA-independent synthesis of arachidonoylethanolamide: a novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptor

    J Biol Chem

    (1994)
  • PC Schmid et al.

    Properties of rat liver N-acylethanolamine amidohydrolase

    J Biol Chem

    (1985)
  • F Snyder

    Metabolism, regulation and function of ether-linked glycerolipids and their bioactive species

  • F Désarnaud et al.

    Anandamide amidohydrolase activity from rat brain microsomes, identification and partial characterization

    J Biol Chem.

    (1995)
  • LM Bornheim et al.

    The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism

    Biochem Biophys Res Commun

    (1993)
  • CB Pert et al.

    Opiate receptor: demonstration in nervous tissue

    Science

    (1973)
  • EJ Simon et al.

    Opioid peptides and opioid receptors

  • WA Devane et al.

    Isolation and structure of a brain constituent that binds to the cannabinoid receptor

    Science

    (1992)
  • R Mechoulam
  • WL Dewey

    Cannabinoid pharmacology

    Pharmacol Rev

    (1986)
  • WA Devane et al.

    A novel probe for the cannabinoid receptor

    J Med Chem

    (1992)
  • WA Devane et al.

    Determination and characterization of a cannabinoid receptor in rat brain

    Mol Pharmacol

    (1988)
  • Cited by (148)

    • Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands

      2019, European Journal of Medicinal Chemistry
      Citation Excerpt :

      Since cholinergic neurons do not express 5-HT6R [84], the higher release of ACh is derived from increased extracellular glutamate [85] and GABA [86–88] levels which in turn lead to the release ACh [89]. The cannabinoid G protein-coupled receptors (GPCRs) consists of two subtypes, CB1R and CB2R [90]. Agonism of hCB1R leads to the well-known psychoactive effects of (−)-trans-Δ9-tetrahydrocanabinol (Δ9-THC) [91].

    View all citing articles on Scopus
    View full text