Transgenic approaches to cognition

doi:10.1016/0959-4388(95)80019-0

Current Opinion in Neurobiology

Volume 5, Issue 2, April 1995, Pages 141-148

https://doi.org/10.1016/0959-4388(95)80019-0 Get rights and content

Abstract

Reverse genetic techniques, including gene ‘knockouts’ and transgenesis, allow defined mutations to be introduced into the mouse genome. The application of these techniques to neurobiology is beginning to provide a bridge between genes and cognition. Specifically, genetically altered mice make it possible to explore molecular mechanisms underlying implicit and explicit forms of learning, short-term and long-term memory, and emotional behaviors. The analysis of these mutant mice has begun to link specific behavioral deficits to defined changes in synaptic physiology.

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Transgenic approaches to cognition

Abstract

Trends Neurosci

Behav Neural Biol

Cell

Cell

Cell

Cell

Cell

Cell

Neurosci Biobehav Rev

Behav Brain Res

Biochem Biophys Res Commun

Cell

Cell

FEBS Lett

Cell

Learning to modulate transmitter release: themes and variations in synaptic plasticity

Annu Rev Neurosci

Forward and reverse genetic approaches to behavior in the mouse

Science

A synaptic model of memory: long-term potentiation in the hippocampus

Nature

Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP

Science

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

Nature