PaperEffect of dequalinium on K1735-M2 melanoma cell growth, directional migration and invasion in vitro
References (24)
- et al.
Effect of microtubule inhibitors on invasion and on related activities of tumor cells
Int Rev Cytol
(1984) - et al.
Anti-invasive activities of experimental chemotherapeutic agents
Crit Rev Oncol Hematol
(1989) - et al.
Selective antimitochondrial agents inhibit calmodulin
Biochem Biophys Res Commun
(1986) - et al.
Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase
J Biol Chem
(1983) - et al.
Phosphorylation of smooth muscle myosin light chain kinase by Ca2+-activated, phospholipid-dependent protein kinase
J Biol Chem
(1985) - et al.
Vinculin, a cytoskeletal substrate of protein kinase C
J Biol Chem
(1983) - et al.
The role of cancer cell motility in invasion
Cancer Metast Rev
(1984) Tumor invasion and metastases-role of the extracellular matrix: rhoads memorial award lecture
Cancer Res
(1986)- et al.
Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation
- et al.
Effects of ring substituents and linker chains on the bifunctional intercalation of diacridines into deoxyribonucleic-acid
Biochemistry
(1980)
Targeting calmodulin for the development of noyel cancer chemotherapeutic agents
Anti-Cancer Drug Design
Inhibition of rodent protein kinase C by the anticarcinoma agent dequalinium
Cancer Res
Cited by (27)
Mechanoresponsive metabolism in cancer cell migration and metastasis
2021, Cell MetabolismCitation Excerpt :Mitochondrial and glycolytic inhibitors have been shown to significantly block the migration and invasion capacity of a variety of cancer cells, including breast cancer (Pacheco-Velázquez et al., 2018; Wu et al., 2018), lung cancer (Jeon et al., 2016), ovarian cancer (Wu et al., 2012), prostate cancer (Senthilkumar et al., 2011; Shiraishi et al., 2015), gastric cancer (Xu et al., 2018), melanoma (Cao et al., 2015; Cerezo et al., 2013; Helige et al., 1992), and osteosarcoma (Sottnik et al., 2011). Many of these inhibitors have demonstrated anti-tumor and anti-metastatic effects in vivo (Dai et al., 2012; Davis et al., 2020; Helige et al., 1992; Wilson et al., 2019; Wu et al., 2012, 2018; Yoshinaka et al., 2006). Inhibiting pyruvate dehydrogenase kinase, which shifts metabolism from aerobic glycolysis toward OXPHOS also inhibits metastasis in vivo (Sun et al., 2010).
Medicinal applications and molecular targets of dequalinium chloride
2021, Biochemical PharmacologyCitation Excerpt :The drug efficacy was also evidenced using two other models of colon carcinoma in mice and rats, and again DQ was found to reduce tumor growth efficiently [33]. The anticancer effects have been characterized in different models, including ovarian cancer [34], prostate cancer [35] and melanoma [36,37]. A marked antiproliferative activity has also been evidenced using NB4 and K562 leukemia cell lines, with the induction of mitochondrial damages, apoptosis and/or necrosis [38,39].
Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways
2014, Leukemia ResearchCitation Excerpt :Thus DQAsomes have been used as mitochondriotropic carriers delivering antitumoral drugs or DNA into mitochondria [6,9–11]. Although cytotoxicity mechanism is not fully understood, DQA has shown to display a potent anticancer activity in cells from different malignancies [9–16]. Antileukemic properties of DQA against the human leukemia cell lines, NB4 derived from acute promyelocytic leukemia, and K562, derived from chronic myeloid leukemia, are being studied in our group.
Dequalinium induces human leukemia cell death by affecting the redox balance
2011, Leukemia ResearchCitation Excerpt :This amphiphilic quinolinium derivative forms liposome-like vesicles positively charged (DQAsomes) which are attracted by the highly negative mitochondrial transmembrane potential of tumor cells [2,3]. Although antitumor mechanism is not fully understood, DQA shows a potent anticancer activity in cells from different malignancies [4–8]. DQA antileukemic properties in the human leukemia cell lines K562 (chronic myeloid leukemia in blastic crisis) and NB4 (acute promyelocytic leukemia) are being studied in our group.
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents
2010, Leukemia ResearchCitation Excerpt :Dequalinium and antimycin A displayed the greatest inhibition of all cytokines by >50%, followed by emetine, benzethonium derivative, alexidine and coralyne (Table 2A). Consistent with our results, dequalinium, alexidine and coralyne have been previously reported to either inhibit cytokine production or induce potent anti-cancer activities [13–16]. Twelve compounds exhibited selective inhibition at high level of >90% (Table 2B), whereas 58 compounds showed selective inhibitory effects at levels of >75% (data not shown).
Small mitochondria-targeting molecules as anti-cancer agents
2010, Molecular Aspects of Medicine