Trends in Endocrinology & Metabolism
Volume 2, Issue 6, November–December 1991, Pages 233-239
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Brief review
The antisteroid RU486 its cellular and molecular mode of action

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Abstract

RU486 is a very powerful antisteroid hormone compound, with antiprogestin and antiglucocorticosteroid clinical applications. High-affinity binding to the receptor ligand-binding domain results in essentially antagonistic function; however, some agonistlike effects have been observed. This review discusses the implications of recent discoveries concerning hsp90 (heat-shock protein Mr≈90,000)-receptor interaction, receptor-DNA binding, and the involvement of transcription factors in the mechanism of action of RU486.

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