Research paperPharmacological characterization of adenosine A2B receptors: Studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes☆
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2018, Biochemical PharmacologyCitation Excerpt :Interestingly, BAY 60-6583 gave a similar time course (providing evidence of desensitization at higher agonist concentrations) to that observed with NECA (Fig. 2c) whilst CGS 21680 did not (Fig. 2d). In addition the concentration-response curve for NECA had a Hill slope significantly less than unity (0.75; p < .001; Partial F test) which would be consistent with the presence of more than one component, similar to that seen previously in HMC-1 cells, which also expresses both A2AAR and A2BAR subtypes [32]. The partial agonist nature of the response to the A2B-selective agonist BAY 60-6583 at the A2BAR was confirmed in combination experiments with NECA (Fig. 5a).
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This work also was supported by NIH Grants R29HL55596 and RR00095.
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