Research paperCross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression☆
References (63)
- et al.
Folate-based thymidylate synthase inhibitors as anticancer drugs
Ann Oncol
(1995) - et al.
Distribution of multidrug resistance-associated P-glycoprotein in normal and neoplastic human tissues
Ann Oncol
(1990) - et al.
Major vault protein LRP related multidrug resistance
Eur J Cancer
(1996) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal Biochem
(1976)- et al.
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing
Eur J Cancer
(1991) - et al.
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate
Eur J Cancer
(1991) - et al.
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity
Eur J Cancer
(1987) - et al.
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro
Biochem Pharmacol
(1985) - et al.
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma
Biochem Pharmacol
(1993) - et al.
The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme
J Biol Chem
(1993)
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
J Biol Chem
(1988)
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil
Biochem Pharmacol
(1995)
Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondrion
J Biol Chem
(1994)
Retentiveness of methotrexate polyglutamates in cultured L1210 cells; evidence against a role for mediated plasma membrane transport outward
Biochem Pharmacol
(1993)
Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates
J Biol Chem
(1990)
Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 cells
Biochem Pharmacol
(1996)
Drug resistance
Resistance to antimetabolites
Determinants of resistance to antifolates: Biochemical phenotypes, their frequency of occurence and circumvention
NCI Monographs
(1987)
Ode to Methotrexate
J Clin Oncol
(1993)
The impact of transport-associated resistance in anticancer chemotherapy
Overexpression of multidrug resistanceassociated protein (MRP) increases resistance to natural product drugs
Cancer Res
(1994)
Multidrug resistance proteins and other drug transport-related resistance to natural product agents
Curr Opion Oncol
(1995)
P-glycoprotein—A marker of cancer-cell behavior
New Eng J Med
(1995)
Fluorouracil: Biochemistry and pharmacology
J Clin Oncol
(1988)
Thymidylate synthase inhibition after administration of 5-fluorouracil with or without leucovorin; implications for treatment with 5-fluorouracil
J Clin Oncol
(1994)
Thymidylate synthase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil
Cancer Res
(1984)
Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
J Clin Oncol
(1989)
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
Cancer Res
(1991)
Biochemical and cellular pharmacology of 1843U89, a novel Benzoquinazoline inhibitor of thymidylate synthase
Cancer Res
(1993)
Molecular design of thymidylate synthase inhibitors
Cited by (0)
- ☆
This study was supported by the Dutch Cancer Society, grant IKA VU 93-627. The authors would like to thank Dr. H. J. Broxterman and Ms. N. Eikelboom for critical reading of the manuscript and Mr. P. Noordhuis for expert technical assistance.
Copyright © 1997 Published by Elsevier Inc.