Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis
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EASL Clinical Practice Guidelines on hepatitis delta virus
2023, Journal of HepatologyAutoimmune serology testing in clinical practice: An updated roadmap for the diagnosis of autoimmune hepatitis
2023, European Journal of Internal MedicineImpact of genetic and environmental factors on autoimmune hepatitis
2021, Journal of Translational AutoimmunityCitation Excerpt :However, very few patients developed AIH after interferon treatment, while the presence of autoantibodies did not affect the response to treatment [106]. Of note, patients with chronic HBV/HDV infection and anti-LKM3 (anti-UGT) autoantibodies were more prone to develop a severe course of HDV infection, albeit they had lower titers of these antibodies compared to AIH-2 patients [107]. Regarding HEV, acute infection has also been reported to associate with the detection of non-specific autoantibodies, suggesting either a cross-reactivity between HEV and liver antigens or even HEV itself acting as a possible AIH trigger [108,109].
Hepatitis
2019, The Autoimmune DiseasesThe clinical usage and definition of autoantibodies in immune-mediated liver disease: A comprehensive overview
2018, Journal of AutoimmunityCutting edge issues in autoimmune hepatitis
2016, Journal of AutoimmunityCitation Excerpt :Importantly, anti-SLA are detectable by ELISA or radio-immuno-assays, but not by immunofluorescence [82,84]. Anti-LKM-3 antibodies, directed to family 1 of UDP-glycuronosyl transferases (UGT1), are a further marker for AIH-2 [85,86], and may also be the only serological maker for AIH. Liver histology is essential to confirm the diagnosis of AIH, as highlighted in all diagnostic scoring systems [10,11].