Clinical and laboratory observation
Cardiotoxic effects of astemizole overdose in children

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Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

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Presented in part at the combined American Association of Poison Control Centers, American Board of Medical Toxicology, American Association of Clinical Toxicology and Canadian Association of Poison Control Centers Annual Meeting, Toronto, Ontario, Canada, Oct. 1, 1991.

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