Muscarinic function in gene-altered miceIdentification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons
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Ultra-LAMA, Ultra-LABA, Ultra-Inhaled Steroids? The Future has Landed
2013, Archivos de BronconeumologiaDevelopmental aspects of the cholinergic system
2011, Behavioural Brain ResearchEffects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices
2010, Neuroscience ResearchCitation Excerpt :In addition to cholinergic synaptic transmissions, ACh influences non-cholinergic synaptic transmissions in the CNS mainly mediated by subtypes of muscarinic ACh receptors (mAChRs) (Nicoll et al., 1990; Levey et al., 1995). It has been reported in hippocampal neurons that M1-mAChR activation (Kremin et al., 2006; Sheridan and Sutor, 1990) or M2-mAChR activation (Dutar and Nicoll, 1988) decreases glutamate release from nerve terminals by regulating N- and L-type Ca2+ channels (Shapiro et al., 2001) and that M2-mAChR activation depresses postsynaptic glutamate sensitivity by hyperpolarizing dendritic cell membranes (Seeger and Alzheimer, 2001), mAChR activation thereby depressing glutamatergic excitatory postsynaptic potentials (Dutar and Nicoll, 1988; Sheridan and Sutor, 1990; Seeger and Alzheimer, 2001; Kremin et al., 2006). M1-mAChR activation also depolarizes somatic membranes (Dutar and Nicoll, 1988; Scuvée-Moreau et al., 1998; Fisahn et al., 2002), and mAChR activation thus enhances neuronal excitability (Sheridan and Sutor, 1990).
Molecular cloning and tissue expression patterns of a small conductance calcium-activated potassium channel gene in turbot (Scophthalmus maximus L.)
2009, Fish and Shellfish ImmunologyCitation Excerpt :Ion channels on the cell plasma membrane form pores that enable selective passage of inorganic ions [1]. Ion channels play a vital role in affecting the actions of excitable cells [2], such as sensory neurons or sensory cells by regulating the duration and frequency of single action potentials, culminating in the initiation of cell signals, which stimulate various metabolic activities. This has therefore been an area of broad interest and intense investigation [3–6].
Modulation of pain transmission by G-protein-coupled receptors
2008, Pharmacology and Therapeutics