Elsevier

Life Sciences

Volume 62, Issues 17–18, 27 March 1998, Pages 1461-1465
Life Sciences

α1-Adrenoceptor subtypes and two receptor systems in vascular tissues

https://doi.org/10.1016/S0024-3205(98)00090-3Get rights and content

Abstract

The subtypes of α1-adrenoceptor are coexpressed in many tissues. We examined the relationship between coexpressed α1-adrenoceptor subtypes and their functions in blood vessels. Rat and rabbit aortas coexpressed three subtypes (α1A, α1B, α1D) and four subtypes (α1A, α1B, α1D, α1L, respectively. In rat aorta however, noradrenaline-induced contraction was mediated predominantly through the α1D subtype, and oxymetazoline produced α1B-mediated contraction. In rabbit aorta, concentration-response curves for noradrenaline were composed of two components (α1B and α1L-mediated), while oxymetazoline produced α1L-mediated contraction. Therefore, the inhibitory actions of some antagonists varied markedly among tissues and agonists. These results demonstrate diversity of the two receptor systems and suggest that the heterogeneity of physiological responses reflects the differences in functional subtypes among tissues and in their sensitivities to agonists and antagonists.

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