BIMU1 Increases Associative Memory in Rats by Activating 5-HT4 Receptors
Section snippets
Animals
Male adult Sprague-Dawley rats (300–350 g) from the IFFA CREDO Company (L'arbresle, France) were used in all experiments. They were individually housed and kept on a 24hr light-dark cycle (lights on at 7:00 a.m. and off at 7:00 p.m.) in a room held at a constant temperature (22°C). Each animal was handled (10 min) every day for 3 days and then deprived of water for 48 hr before training.
Apparatus and training procedure
The olfactory training apparatus was a rectangular box made of wire mesh (30 × 30 × 50 cm). A conical odor
Experiment 1
The four groups improved their performance across sessions, reaching a correct response score of 80% or better on session 5 (see Table 1).
A MANOVA indicated a group difference across the five sessions for the percentage of correct responses [F(3,24) = 3.79, p = 0.024]. Indeed, following the injection on session 3, the three BIMU1 groups improved their performance compared to the saline groups. The improvement in the correct response rate was not as great for the BIMU1 1 and 5 groups as for the
DISCUSSION
The present results show that BIMU1 is a potential memory facilitating agent. Following the injection of BIMU1 (10 mg/kg), a highly significant improvement in performance (higher correct response rate) was apparent in comparison to the saline treated (CONTROL) animals, assessed using an olfactory association learning test. A similar but more modest effect was observed with BIMU1 (1 and 5 mg/kg). This improvement was partially maintained during the fourth and the fifth sessions. The latency
Acknowledgements
This work was supported by the CNRS. The authors are grateful for the expert secretarial assistance of Michelle Bauget and for the technical assistance of Alain Bouquerel.
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