Enantiospecific total synthesis of 8- and 12-hydroxyeicosatetraenoic acid

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Abstract

The R- and S-isomers of 8- and 12-hydroxyeicosatetraenoic acid (8- and 12-HETE) were synthesized from dimethyl matate derived precursors.

Both enantiomers of the title arachidonate metabolites were synthesized from dimethyl malate derived precursors.

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References (11)

  • G.L. Bundy et al.

    J. Biol. Chem.

    (1986)
  • G. Just and Z.Y. Wang, private...
  • A.R. Brash

    Circulation

    (1985)
    F.M. Cunningham et al.

    Brit. J. Pharm.

    (1986)
  • P. Mosset, P. Yadagiri, S. Lumin, J. Capdevila, and J.R. Falck, preceding...
  • J. Capdevila et al.M. Johnson et al.

    Essays in Biochemjstry

    (1983)
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