Endogenous Opioid Regulation of Hippocampal Function
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Reproductive and developmental toxicity assessments of LPM3480392, a novel mu opioid receptor biased agonist in rats
2023, Reproductive ToxicologyEffects of prenatal opioid exposure on synaptic adaptations and behaviors across development
2023, NeuropharmacologyCitation Excerpt :The hippocampus is particularly susceptible to perturbation from opioid exposure due to opioid-mediated regulation of hippocampal plasticity (Drake et al., 2007; Stumm et al., 2004; Simmons and Chavkin, 1996). Indeed, co-release of opioids with glutamate is required for LTP induction at the lateral perforant pathway (PP) onto dentate gyrus (DG) granule cells and CA3 pyramidal neurons, as well as at mossy fiber projections (originating from DG granule cells) to CA3 neurons (Drake et al., 2007; Stumm et al., 2004; Simmons and Chavkin, 1996). It is not surprising that opioid exposure at any age has substantial effects on hippocampal development and plasticity resulting in altered learning and cognitive function in offspring.
Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula
2020, Neurobiology of StressModeling prenatal opioid exposure in animals: Current findings and future directions
2018, Frontiers in NeuroendocrinologyCitation Excerpt :One brain region that has been investigated extensively following prenatal opioid exposure is the hippocampus. Opioids have a profound influence on the activity of hippocampal neurons (Simmons and Chavkin, 1996; Drake et al., 2007) as well as on hippocampal neurogenesis (Sargeant et al., 2008; Zhang et al., 2016). The effects of opioid may be particularly relevant to spatial learning in the context of goal-directed behaviors (Retailleau et al., 2012).