Chapter 27 A role for cAMP in regeneration during development and after injury
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Iron prevents demyelination of frog sciatic nerves
2017, Environmental Toxicology and PharmacologyQuercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice
2017, Journal of Nutritional BiochemistryCitation Excerpt :The activation of neuronal intrinsic growth is an important feature of axon regeneration after peripheral nerve injury. Recent studies have shown that intracellular cAMP is increased after peripheral nerve injury [28], and dorsal root ganglion (DRG) db-cAMP (a cAMP analog) injection is sufficient to initiate neuronal intrinsic growth capacity and promote the central branch of DRG neurons to regenerate [29,30]. To examine whether quercetin could active neuronal intrinsic capacity, we investigated cAMP and growth-associated protein-43 (Gap-43; a downstream effector protein in the cAMP signal pathway) [31] expression levels in the L4 and L5 spinal cord after sciatic nerve-crush injury.
Inhibiting cortical protein kinase A in spinal cord injured rats enhances efficacy of rehabilitative training
2016, Experimental NeurologyHindbrain raphe stimulation boosts cyclic adenosine monophosphate and signaling proteins in the injured spinal cord
2014, Brain ResearchCitation Excerpt :We tested this reasoning with respect to the important intracellular signaling cascade initiated by cyclic adenosine monophosphate (cAMP). Increased cAMP is known to facilitate recovery from SCI (Nikulina et al., 2004; Pearse et al., 2004; Qiu et al., 2002), probably by acting in several distinct ways. It subdues the inhibitory actions of the proteins produced by myelin breakdown on axonal growth, it modulates glia-propagated inflammation and it leads to upregulated expression of pro-inflammatory cytokines such as TNFα (Christiansen et al., 2011; Gerlo et al., 2011; Ghosh et al., 2012; Zhang et al., 2002).
The challenges of respiratory motor system recovery following cervical spinal cord injury
2014, Progress in Brain Research