ArticlesDopaminergic and Cholinergic Interaction in Cataleptic Responses in Mice
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Animals
Healthy male ddY albino mice (7 week-old mice; 30–35 g), purchased from Kyudo Animal Laboratory (Kumamoto, Japan), were allowed free access to food and water. The mice were housed and all trials were conducted at an environmental temperature of 23 ± 1°C, with a 12 L:12 D cycle (0700–1900). All experiments were performed by using 8-week-old mice weighing 35–40 g.
Measurement of Catalepsy
Catalepsy responses were measured using the suspended bar method. Mice were placed individually on a plastic board (25 × 35 cm) with a
Effects of Dopamine Receptor Agonists on Cataleptic Responses Induced by SCH23390 or Haroperidol
As shown in Fig. 1, pretreatment with SKF38393 (1.0–10 mg/kg IP) did not affect haloperidol (0.3 mg/kg) catalepsy, but inhibited SCH23390 (0.3 mg/kg) catalepsy in a U-shape fashion, the significant doses being at 1.0, 2.5, and 5.0 mg/kg (Fig. 1A).
Apomorphine (0.01–1.0 mg/kg IP) itself induced cataleptic responses and exhibited a small bell-shaped dose-response curve. Apomorphine at 0.01–0.1 mg/kg altered the haloperidol catalepsy response in a bell-shaped manner, at 0.25 and 0.5 mg/kg
Discussion
The results of this study suggest that SCH23390, haloperidol, physostigmine, and pilocarpine exert their cataleptogenic action via dopaminergic and cholinergic mechanisms, but none of them has the identical mechanism as the others.
Although D1 and D2 receptor antagonists exert synergistic effects between D1 and D2 receptor blockade [24], in this study, SCH23390 catalepsy was altered by SKF38393 in a U-shaped manner, whereas haloperidol catalepsy was not affected. SKF38393 may be a partial
Acknowledgements
This work was supported in part by a grant-in aid for scientific research (no. 06670964) from the Ministry of Education Sciences and Culture, Japan.
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