Regulators of cell death

doi:10.1016/S0168-9525(00)89010-1

Trends in Genetics

Volume 11, Issue 3, March 1995, Pages 101-105

https://doi.org/10.1016/S0168-9525(00)89010-1 Get rights and content

A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.

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Trends in Genetics

ReviewRegulators of cell death

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Regulators of cell death