Detection of aminoglycoside ototoxicity by high-frequency auditory evaluation: Selected case studies**
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Cited by (54)
Hearing Loss: Environmental, Sensorineural, Drug Induced (Cisplatinin, Antibiotics)
2022, Comprehensive PharmacologyExtended high frequency hearing and speech perception implications in adults and children
2020, Hearing ResearchCitation Excerpt :By the second decade of life, significant decreases in sensitivity have occurred, and continue to progress in a basal to apical pattern. EHF hearing is highly susceptible to ototoxic drugs (Fausti et al., 1993, 1984; Garinis et al., 2018) otitis media with effusion (Cordeiro et al., 2018; Hunter et al., 1996) and impulse noise due to firearm use (Fausti et al., 1981; Laffoon et al., 2019). However, variability of the impact to EHF hearing is large among all these risk factors, presumably due to genetic variants.
Inner Hair Cell and Neuron Degeneration Contribute to Hearing Loss in a DFNA2-Like Mouse Model
2019, NeuroscienceCitation Excerpt :This result can be associated with the initial reduction of hearing sensitivity (< 60 dB) at high frequencies, which progresses to middle and low frequencies with age in DFNA2 patients (Dominguez and Dodson, 2012). Also, ototoxic drugs that alter KCNQ4 channel function exhibit a similar degenerative profile, where OHCs from basal turns are more sensitive to their deleterious effects (Fausti et al., 1984; Leitner et al., 2011; Sheppard et al., 2015). However, this expression pattern differs from that reported by others.
High frequency hearing thresholds and product distortion otoacoustic emissions in cystic fibrosis patients
2015, Brazilian Journal of OtorhinolaryngologyCitation Excerpt :HFA evaluates pure tone air conduction thresholds in the 9–20 kHz range, depending on the equipment. This is an important test for the early detection of hearing loss caused by damage to the base of the cochlea, as occurs in cases of ototoxicity, because it allows the detection of hearing loss before reaching the conventionally measured frequency range (250–8000 Hz).15,16 The literature presents some studies on CF patients evaluating hearing by HFA.
Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin
2009, NeuroscienceCitation Excerpt :Even with the use of neonatal HCs, in our chronic experiment we observed fluorescence consistent with hROS formation that was most prominent in OHCs, was graded from base to apex, and was furthermore graded from the first to the third row of OHCs and IHCs. All of these features reflect the sensitivity of HCs to GM in the in vivo cochlea (e.g. Fausti et al., 1984; Hinojosa et al., 2001). Our studies confirm previous in vitro findings (Richardson and Russell, 1991; Forge and Richardson, 1993; Battaglia et al., 2003) of differential HC sensitivity to aminoglycoside damage.
Antioxidant gene therapy can protect hearing and hair cells from ototoxicity
2004, Molecular TherapyCitation Excerpt :A serious limitation in the treatment with aminoglycoside antibiotics is their potential nephrotoxic and ototoxic side effects [1–3]. Aminoglycoside-induced hearing loss and inner ear pathology have been well studied in humans and animal models [3–5]. The lesion usually starts from the base of the cochlea and, correspondingly, high frequencies are affected first and to a greater extent.
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Supported by the Medical Research Service of the Veterans Administration.
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Audiology Research Laboratory, VA Medical Center, 3710 S.W. U.S. Veterans Hospital Road, Portland, OR 97201.
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Infections Disease Section, Portland VA Medical Center.
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Kresge Hearing Research Laboratory, Oregon Health Sciences University.