Elsevier

Food and Chemical Toxicology

Volume 34, Issues 11–12, November–December 1996, Pages 1151-1153
Food and Chemical Toxicology

Zero interaction response surfaces for combined-action assessment

https://doi.org/10.1016/S0278-6915(97)00087-2Get rights and content

Abstract

Combined-action assessment requires first the calculation of combination effects expected for the case of no interaction. In a second step the experimental combination effects have to be compared to the expected ones in order to classify the combination as synergistic or antagonistic. Adopting the response surface methodology, a new procedure for the calculation of zero interaction response surfaces which can be applied both to various criteria for defining zero interaction and to various types of dose-response relations is proposed. The approach requires only information from single-agent dose-response relations, but provides nevertheless a comprehensive overview over the complete dose range under study. It can replace the tedious isobolographic analysis if the dose-additivity criterion is adopted.

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