Diversity of DNA topoisomerases I and inhibitors
References (200)
- et al.
Eukaryotic DNA topoisomerases I
Biochim Biophys Acta
(1995) - et al.
Topoisomerase Poisons: Harnessing the dark side of enzyme mechanism
J Biol Chem
(1995) Recent studies of DNA topoisomerases
Biochim Biophys Acta
(1987)- et al.
Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase
J Biol Chem
(1992) - et al.
A hypersensitive recombination mutation in S cerevisiae identifies a novel eukaryotic topoisomerase
Cell
(1989) - et al.
ATP-dependent DNA topoisomerase from D. melanogaster reversibly catenates duplex DNA rings
Cell
(1980) - et al.
Cloning of mouse cDNA encoding DNA topoisomerase I and chromosomal location of the gene
Gene
(1993) - et al.
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance
J Biol Chem
(1993) - et al.
Expression of the topoisomerase I gene in serum stimulated human fibroblasts
Biochim Biophys Acta
(1990) - et al.
Identification of Saccharomyces cerevisiae mutants deficient in DNA topoisomerase I activity
J Biol Chem
(1984)
Mitotic recombination in the rDNA of S cerevisiae is suppressed by the combined action of DNA topoisomerase I and II
Cell
A subthreshold level of DNA topoisomerase leads to the excision of yeast rDNA as extrachromosomal rings
Cell
Mechanisms of camptothecin resistance in Yeast DNA topoisomerase I mutants
J Biol Chem
Identification and DNA sequence of the Shope fibroma virus DNA topoisomerase I gene
Virology
Site-specific DNA cleavage by Vaccinia virus DNA topoisomerase I. Role of nucleotide sequence and DNA secondary structure
J Biol Chem
SFV topoisomerase: sequence specificity in a genetically mapped interval
Virology
Reconstitution of human topoisomerase I by fragment complementation
J Mol Biol
The domain organization of human topoisomerase I
J Biol Chem
Biochemical and Biophysical analyses of recombinant forms of human topoisomerase I
J Biol Chem
Phosphorylation of mammalian DNA topoisomerase I and activation by protein C
J Biol Chem
CPT-11 (irinoteccan) in the treatment of colorectal cancer
Eur J Cancer
The clinical status of irinotecan (CPT-11), a novel water soluble camptothecin analogue: 1996
Crit Rev Oncol/Hematol
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
J Biol Chem
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin
J Biol Chem
A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin
Cell
Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene
Cell
DNA topoisomerases
Annu Rev Biochem
DNA topoisomerases
Annu Rev Biochem
DNA topoisomerases
Annu Rev Biochem
DNA topoisomerase poisons as antitumor drugs
Annu Rev Biochem
Mammalian DNA topoisomerase I and its inhibitors
A hyper-recombination mutation in S cerevisiae identifies a novel eukaryotic cell phase
Cell
Human TOP3: a single copy gene encoding DNA topoisomerase III
Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectesia phenotype
The yeast type 1 topoisomerase top3 interacts with sgsl, a DNA helicase homolog: a potential eukaryotic reverse gyrase
Mol Cell Biol
Partial purification of protein from calf thymus
Biochemistry
HeLa toposiomerase I
Methods enzymol
DNA topoisomerase I from mitochondria of Xenopus laevis oocytes
Eur J Biochem
ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells
Purification and characterization of a type I DNA topoisomerase from calf thymus mitochondria
Biochemistry
DNA topoisomerase I is essential in Drosophila melanogaster
Targeted disruption of the mouse topoisomerase I gene by camptothecin selection
Mol Cell Biol
Conditional growth of Escherichia coli caused by expression of vaccinia virus DNA topoisomerase I
J Bacteriol
Expression of human DNA topoisomerase I in Yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin
Cancer Res
Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin
Cancer Res
Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle
Isolation of type I and II DNA topoisomerase mutants from fission yeast: Single and double mutants show different phenotypes in cell growth and chromatin organization
EMBO J
Using yeast to understand drugs that target topoisomerases
Ann NY Acad Sci
Differential poisoning of human and Aspergillus nidulans DNA topoisomerase 1 by bi- and terbenzimidazoles
Biochemistry
A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties
Cited by (125)
3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt
2018, Leukemia ResearchCitation Excerpt :The majority of anticancer drugs target the DNA in tumor cells, inducing various types of DNA damage. The most effective anticancer drugs are DNA topo I or II inhibitors, which stabilize otherwise transient DNA and topo I or topo II associations that form “cleavable complexes” which are then converted into DNA double-strand breaks (DSBs) [2–7]. The induction of DNA damage as well as DSBs triggers a complex formation of essential factors and highly coordinated series of events known as the DNA damage response (DDR) [8,9].
Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala: In vitro, in vivo and in silico approach
2016, South African Journal of BotanyCytogenetic evidence that DNA topoisomerase II is not involved in radiation induced chromsome-type aberrations
2015, Mutation Research - Genetic Toxicology and Environmental MutagenesisBiological potential of carbazole derivatives
2015, European Journal of Medicinal ChemistryCitation Excerpt :G-quadruplexes are formed by association of two or four separate strands of DNA (intermolecular quadruplex) (Fig. 31b) or by rolling up a single strand (intramolecular quadruplex) with parallel or antiparallel orientation [92,94–96,139]. It is believed that the therapeutic effectiveness of such ligands in treatment of neoplasmic diseases is attributed to inhibition or poisoning of some DNA enzymes, in particular topoizomerases and telomerase [92,94,96,139–145]. Topoizomerases are the enzymes which in vivo unfold the double DNA helix to make the matrix accessible to replication or transcription enzymes.