Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein☆
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2018, The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying MechanismsInfection, systemic inflammation, and Alzheimer's disease
2015, Microbes and InfectionCitation Excerpt :Reactive microglia and astrocytes adjacent to Aβ plaques is a common observation in the AD brain [14]. It is thought that activated glia is at first beneficial for degrading Aβ plaques [15]. However, chronic inflammation leads to the production of several cytokines that have been demonstrated to exacerbate other AD pathologies [16].
The role of astrocytes in amyloid β-protein toxicity and clearance
2012, Experimental NeurologyAstrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains
2011, FEBS LettersCitation Excerpt :In an AD patient’s brain, reactive astrocytes are integral components of neuritic plaques [21,22]. Aβ has been detected within astrocytes surrounding both neuritic and diffuse amyloid plaques as well as in cultured glial cells [23–28]. In addition, Aβ accumulation within astrocytes is not dependent on the local presence of plaques, since activated astrocytes exhibiting prominent intracellular Aβ42 deposits often populate the cortical molecular layer, even when it is completely devoid of amyloid plaques [29].
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This research was supported by grants-in-aid from the Ministry of Education, Science and Culture of Japan (05807056 and 07264244), and the Alzheimer Society of B.C., as well as donations from individual British Columbians.