The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine1
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Acknowledgements
We gratefully acknowledge a grant from the National Institute on Drug Abuse 09374 to D.G.D., a Minority Supplement from the National Institute on Drug Abuse to R.L.O., and a Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression to W.A.D.
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A preliminary report of this work was presented at the June 1997 Symposium on the Cannabinoids sponsored by the International Cannabinoid Research Society, held at Stone Mountain, GA, USA.
Copyright © 1997 Elsevier Science Ireland Ltd. All rights reserved.