Inhibition of nicotine-induced hippocampal norepinephrine release in rats by alpha-conotoxins MII and AuIB microinjected into the locus coeruleus
Section snippets
Acknowledgements
This work is supported by NIDA DA03977 (to B.M.S.), MH53631 and GM48677 (to J.M.M.).
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2006, NeuropharmacologyCitation Excerpt :These postsynaptic events were blocked by 100 μM but not 3 μM DHβE indicating that these receptors are heteromeric nicotinic receptors and non-α4β2 receptors. This study focused on the role of α3β2 and/or α6βX containing, and α3β4 nicotinic receptors, using the selective neurotoxins, α-conotoxin MII and α-conotoxin AuIB, respectively (Cartier et al., 1996; Luo et al., 1998; Fu et al., 1999; Grady et al., 2001). The results from this study demonstrate there are several populations of nicotinic receptors that differentially affect postsynaptic glutamatergic neurotransmission in cardiac vagal neurons.
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