Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
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PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON
2019, Seminars in ImmunologyCitation Excerpt :Genetic defects in type I IFN signaling are associated with susceptibility to mycobacterial and viral infections and autoimmunity [43–46]. Additionally, deletion breakpoints within or in close proximity to the type I IFN locus have been identified in several malignancies including leukaemia, melanoma, glioma, bladder cancer and lung cancer cell lines [47–51] and have been identified as potential biomarkers for response to immunotherapy [52]. Characterization of the biological significance of defects in IFNε1 expression have been obscured by a delay in the development of available reagents including probes for transcriptome analysis, however deletions of IFNε1 have been identified as the most common type I IFN gene loss at chromosome 9p21 in bladder cancer cell lines [53].
Interaction in vivo between the Two Matrix Attachment Regions Flanking a Single Chromatin Loop
2009, Journal of Molecular BiologyInterferon alpha-2b
2007, xPharm: The Comprehensive Pharmacology ReferenceInterferon-alpha
2007, xPharm: The Comprehensive Pharmacology ReferenceA reciprocal t(4;9)(q31;p22) in a solitary neurofibroma
2005, Cancer Genetics and CytogeneticsCitation Excerpt :The 4q31 breakpoint has been reported in a malignant peripherial nerve sheath tumor [11], in myelodysplastic syndromes, and acute and mixed lineage leukemias [10]. The 9p22 breakpoint is a recurring breakpoint reported in overlapping deletions of the short arm of chromosome 9 occurring in acute lymphoblastic leukemia and gliomas [12]. These deletions include the interferon gene cluster and the MLLT3 gene.
Pooled Analysis of Loss of Heterozygosity in Breast Cancer: A Genome Scan Provides Comparative Evidence for Multiple Tumor Suppressors and Identifies Novel Candidate Regions
2003, American Journal of Human GeneticsCitation Excerpt :The peak at 18p11.32 is near EPB41L3 (MIM 605331) (Tran et al. 1999). Other, less striking peaks include 9p21.3 (CDKN2A/p16 [MIM 600160] and IFNA4 [MIM 147564]) (Olopade et al. 1992; Milde-Langosch et al. 2001), 6q25.1 (ESR1 [MIM 133430] and IGF2R [MIM 147280]) (Murphy et al. 1996; Chen et al. 2002), 1p36.3 (SKI [MIM 164780] and TP73 [MIM 601990]) (Shinagawa et al. 2001; Stiewe and Putzer 2002), and 4q35.1 (FAT [MIM 600976]) (Mahoney et al. 1991). Figure 6A shows the relationship between the maximum -log10 P on each chromosome arm and the total number of informative marker observations per arm.