Conformationally restricted inhibitors of the high affinity L-glutamate transporter

doi:10.1016/S0960-894X(00)80103-1

Bioorganic & Medicinal Chemistry Letters

Volume 3, Issue 1, January 1993, Pages 115-121

https://doi.org/10.1016/S0960-894X(00)80103-1 Get rights and content

Abstract

A series of acidic amino acids has been prepared and evaluated in an effort to identify the structural features required for binding to and inhibiting the high affinity uptake system that clears L-glutamate from the synaptic cleft during excitatory amino acid-mediated neurotransmission in the mammalian CNS.

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Conformationally restricted inhibitors of the high affinity L-glutamate transporter

Abstract

Neuron

Brain Res. Bull.

J. Neurosci.

Neurosci. Lett.

Trends Pharmac. Sci.

J. Med. Chem.

Neurosci. Lett.

J. Med. Chem.

Ph. D. Thesis

Neuroscience Lett.

J. Org. Chem.

Conformationally restricted inhibitors of the high affinity $L$ -glutamate transporter