Current Biology
Volume 10, Issue 13, 1 June 2000, Pages R475-R477
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Synaptic transmission: Spillover in the spotlight

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Abstract

Fast neurotransmission in the brain is typically mediated by local actions of transmitters at ionotropic receptors within synaptic contacts. Recent studies now reveal that, in addition to point-to-point signaling, amino-acid transmitters mediate diffuse signaling at extrasynaptic metabotropic receptors.

Keywords

Neuroscience
Pharmacology

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