Trends in Cell Biology
Volume 7, Issue 9, September 1997, Pages 353-361
Journal home page for Trends in Cell Biology

Review
The search for physiological substrates of MAP and SAP kinases in mammalian cells

https://doi.org/10.1016/S0962-8924(97)01105-7Get rights and content

Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.

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