Pharmacology and Neurochemistry of Apomorphine*
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2021, CellCitation Excerpt :Due to the high homology of dopamine receptors, most dopaminergic drugs are highly polypharmacologic because they frequently target multiple dopamine receptors and other aminergic GPCRs (Butini et al., 2016; Roth et al., 2004). Non-selective dopamine agonists, including PD drugs apomorphine (Di Chiara and Gessa, 1978) and bromocriptine (Parkes et al., 1976), have been proposed to be more effective than selective drugs for treating complex CNS diseases (Roth et al., 2004). On the other hand, highly selective dopamine receptor ligands are important pharmacological tools for functional investigation.
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Much of the work reported herein was supported by grants from the Consiglio Nazionale delle Richerche, Rome.
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