Review
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases

https://doi.org/10.1016/S1286-4579(03)00068-6Get rights and content
Under an Elsevier user license
open archive

Abstract

Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding via specific receptors, adenosine activates endogenous protective mechanisms aiming at the restoration of tissue homeostasis. While adenosinergic downregulation of tissue damage is beneficial in acute inflammation, chronic suppression of the immune system by adenosine may account for immunoparalysis in long-term septic patients.

Keywords

Adenosine
Receptor
Sepsis
Infectious disease

Cited by (0)