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Phospholipase C-γ1: Regulation of enzyme function and role in growth factor-dependent signal transduction

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Abstract

Phospholipase Cγ1 (PLC-γ1), a tyrosine kinase substrate, is a multi-domain molecule that modulates the intracellular levels of the second messenger molecules: Ca2+ and diacylglycerol. Although a wide variety of growth factor receptor tyrosine kinases phosphorylate and activate PLC-γl, the biological role and necessity of this signal transduction element in mitogenesis has remained unclear. Recent results, however, point to a more essential role than was suggested by initial studies. Also, biochemical studies have indicated a putative means for the intramolecular repression of PLC-γ1 activity and provide a means for interpreting activation signals through a derepression mechanism.

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