Archival Reportα2 Adrenergic and Imidazoline Receptor Agonists Prevent Cue-Induced Cocaine Seeking
Section snippets
Animals
Male Sprague Dawley rats (initial weight 250–300 g; Charles River, Raleigh, North Carolina) were single- or pair-housed in a temperature- and humidity-controlled animal facility at the Medical University of South Carolina accredited by the Association for Assessment and Accreditation of Laboratory Animal Care. Rats were housed under a reversed 12-hour light/dark cycle (lights off at 6:00 am), with ad libitum food and water (except for food self-administration study, described below). All
Results
For all rats undergoing cocaine self-administration (n = 189), the means (± SEM) for the last 2 days of self-administration were 38.5 (±.9) and 39.6 (±1.0) infusions (approximately 20 mg/kg per day) and 54.7 (±3.7) and 53.6 (±3.2) active lever presses. The mean (± SEM) active lever presses for days 1 and 7 of extinction were 84.3 (±3.2) and 18.2 (±.8), respectively, for animals that received no treatment on extinction days. Unless noted, there were no significant differences for responding on
Discussion
Our results indicate that the I1 receptor-preferring agonist moxonidine is a potential therapeutic option for maintaining cocaine abstinence. Moxonidine reduced cocaine seeking triggered by either drug-associated cues or cocaine prime without signs of sedation. These reinstatement findings highlight the potential functional importance of the relatively unknown imidazoline signaling system in drug addiction. In addition, the current studies revealed that α2 adrenergic receptor agonists and CRF
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2021, Neuroscience LettersCitation Excerpt :rs1048101 plays an important role in various brain diseases, such as Alzheimer’s disease and substance use disorder [46,47]. ADRA1A antagonist attenuated cocaine-induced reinstatement of cocaine-seeking behavior [48,49], which suggests that suppressing the ADRA1A receptor may decrease the efficiency of the transition to addiction. Daily heroin dosage reflects the tolerance of addicts to heroin.
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