Cell
Volume 120, Issue 4, 25 February 2005, Pages 497-512
Journal home page for Cell

Review
DNA Repair, Genome Stability, and Aging

https://doi.org/10.1016/j.cell.2005.01.028Get rights and content
Under an Elsevier user license
open archive

Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability, metabolism, and aging. We conclude with a general discussion of the role of mutant mice in aging research and avenues for future investigation.

Cited by (0)