Cell
Volume 143, Issue 7, 23 December 2010, Pages 1136-1148
ArticleWnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
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Graphical Abstract
Highlights
► Canonical Wnt signaling causes the sequestration of GSK3 inside endosomal vesicles ► Protease protection and cryoimmuno-EM show that GSK3 is sequestered inside MVBs ► The MVB-forming ESCRT components HRS/Vps27 and Vps4 are required for Wnt signaling ► In pulse-chase experiments overall cellular protein half-life is prolonged by Wnt3a
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These authors contributed equally to this work
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Present address: Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0525, USA
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