Cell
Volume 153, Issue 1, 28 March 2013, Pages 216-227
ArticlePhospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy
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Graphical Abstract
Highlights
► Conditional deletion of PLCε in mice protects against stress-induced hypertrophy ► PLCε is in a complex at the nuclear envelope with regulators and downstream targets ► PLCε is critical for regulation of local nuclear PKD activity and Ca2+ release ► PI4P in the perinuclear Golgi is the substrate for PLCε
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These authors contributed equally to this work
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Present address: Wistar Institute, Philadelphia, PA 19104, USA
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Present address: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229-3039, USA
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