Chemistry & Biology
Volume 13, Issue 2, February 2006, Pages 115-116
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Targeting HSP90 to Halt Neurodegeneration

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Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis [1].

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