Cell Metabolism
Volume 16, Issue 5, 7 November 2012, Pages 634-644
ArticleMetabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
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Graphical Abstract
Highlights
▸ Dioxin altered hepatic CES3, resulting in elevated serum azelaic acid monoesters ▸ Decreased CES3 expression is due to proinflammatory cascade activation ▸ The CES3-mediated metabolic changes are associated with steatohepatitis ▸ Azelaic acid monoester is an indicator of dioxin exposure and steatohepatitis
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Present address: Department of Anatomy and Regenerative Biology, Osaka City University, Osaka 545-8585, Japan
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Present address: Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
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These authors equally contributed to this work
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