Elsevier

Molecular Brain Research

Volume 133, Issue 1, 5 January 2005, Pages 162-165
Molecular Brain Research

Short communication
Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

https://doi.org/10.1016/j.molbrainres.2004.09.023Get rights and content

Abstract

In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.

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Acknowledgement

This work was supported by the Arvo and Lea Ylppö Foundation and Academy of Finland.

References (19)

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Cited by (10)

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    Although not statistically different, it is interesting to note that RGS4 mRNA levels were elevated in both brain regions at all time points examined. These findings differ from those of a previous report where in situ hybridization data indicated that RGS4 mRNA levels were decreased in hippocampal pyramidal neurons and in the retrosplenial cortex but not in the piriform cortex of 10 day old but not in adult FMR1 mice (Tervonen et al., 2005). The reason for this discrepancy may relate to subtle differences in the age of the animals used in the two studies, or to the lower degree of spatial resolution in real-time RT-PCR compared to in situ hybridization.

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