Skip to main content
SpringerLink
Log in

The Human Nm23/Nucleoside Diphosphate Kinases

  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

Abstract

Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes phosphoryl transfer from a nucleoside triphosphate toa nucleoside diphosphate, is ubiquitously found in organisms from bacteria to human. Overthe past 10 years, eight human genes of the nm23/NDP kinase family have been discoveredthat can be separated into two groups based on analysis of their sequences. In addition tocatalysis, which may not be exhibited by all isoforms, evidence for regulatory roles has comerecently from the discovery of the genes nm23 and awd, which encode NDP kinases and areinvolved in tumor metastasis and Drosophila development, respectively. Current work showsthat the human NDP kinase genes are differentially expressed in tissues and that their productsare targeted to different subcellular locations. This suggests that Nm23/NDP kinases possessdifferent, but specific, functions within the cell, depending on their localization. The roles ofNDP kinases in metabolic pathways and nucleic acid synthesis are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  • Adams, V., Bosch, W., Schlegel, J., Wallimann, T., and Brdiczka, D. (1989). Biochim. Biophys. Acta. 981, 213-225.

    Google Scholar 

  • Adams, V., Griffin, L., Towbin, J., Gelb, B., Worley, K., and McCabe, E. R. (1991). Biochem. Med. Metab. Biol. 45 , 271-291.

    Google Scholar 

  • Amendola, R., Martinez, R., Negroni, A., Venturelli, D., Tanno, B., Calabretta, B., and Raschella, G. (1997). J. Natl. Cancer Inst. 89, 1300-1310.

    Google Scholar 

  • Arora, K. K., and Pedersen, P. L. (1988). J. Biol. Chem. 263, 17422-17428.

    Google Scholar 

  • Backer, J. M., Mendola, C. E., Kovesdi, I., Fairhurst, J. L., O'Hara, B., Eddy, R. L., Jr., Shows, T. B., Mathew, S., Murty, V. V., and Chaganti, R. S. (1993). Oncogene 8, 497-502.

    Google Scholar 

  • Barraud, P., Amrein, L., Dobremez, E., Dabernat, S., Massé, K., Larou, M., Daniel, J. Y., and Landry, M. (1999). Proc. 3rd Intern. Congr. Genet Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. P1.

  • Berg, P., and Joklik, W. K. (1953). Nature (London) 172, 1008-1009.

    Google Scholar 

  • Bessman, S. P., and Carpenter, C. L. (1985). Annu. Rev. Biochem., 831-862.

  • Biggs, J., Tripoulas, N., Hersperger, E., Dearolf, C., and Shearn, A. (1988). Genes Develop. 2, 1333-1343.

    Google Scholar 

  • Biggs, J., Hersperger, E., Steeg, P. S., Liotta, L. A., and Shearn, A. (1990). Cell 63, 933-940.

    Google Scholar 

  • Brdiczka, D., Beutner, G., Ruck, A., Dolder, M., and Wallimann, T. (1998). Biofactors. 8, 235-242.

    Google Scholar 

  • Cheng, Y. C., Agarwal, R. P, and Parks, R. E., Jr. (1971). Biochemistry. 10, 2139-2143.

    Google Scholar 

  • Cheng, Y. C., Robison, B., and Parks, R. E., Jr. (1973). Biochemistry. 12, 5-10.

    Google Scholar 

  • Chiadmi, M., Morera, S., Lascu, I., Dumas, C., Le Bras, G., Veron, M., and Janin, J. (1993). Structure 1, 283-293.

    Google Scholar 

  • Dearolf, C. R., Hersperger, E., and Shearn, A. (1988). Develop.Biol. 129, 159-168.

    Google Scholar 

  • Dooley, S., Seib, T., Engel, M., Theisinger, B., Janz, H., Piontek, K., Zang, K. D., and Welter, C. (1994). Human Genet. 93, 63-66.

    Google Scholar 

  • Dzeja, P. P., Zeleznikar, R. J., and Goldberg, N. D. (1998). Mol. Cell Biochem. 184, 169-182.

    Google Scholar 

  • Engel, M., Seifert, M., Theisinger, B., Seyfert, U., and Welter, C. (1998). J. Biol. Chem. 273, 20058-20065.

    Google Scholar 

  • Erent, M., Gonin, P., Tissier, P., Cherfils, J., Giartoso, A., Konrad, M., Sarger, C., and Lascu, I. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T21.

  • Escobar Galvis, M. L., Hakansson, G., Alexciev, K., and Knorpp, C. (1999). Biochimie 81, 1089-1096.

    Google Scholar 

  • Fearon, E. R. (1997). Science 278, 1043-1050.

    Google Scholar 

  • Fukuchi, T., Nikawa, J., Kimura, N., and Watanabe, K. (1993). Gene 129, 141-146.

    Google Scholar 

  • Gervasi, F., D'Agnano, I., Vossio, S., Zupi, G., Sacchi, A., and Lombardi, D. (1996). Cell Growth Different. 7, 1689-1695.

    Google Scholar 

  • Gilles, A. M., Presecan, E., Vonica, A., and Lascu, I. (1991). J. Biol. Chem. 266, 8784-8789.

    Google Scholar 

  • Glaze, R. P., and Wadkins, C. L. (1967). J. Biol. Chem. 242, 2139-2150.

    Google Scholar 

  • Gonin, P., Xu, Y., Milon, L., Dubernat, S., Morr, M., Kumar, R., Lacombe, M. L., Janin, J., and Lascu, I. (1999). Biochemistry 38, 7265-7272.

    Google Scholar 

  • Green, D., and Kroemer, G. (1998). Trends Cell Biol. 8, 267-271.

    Google Scholar 

  • Hanks, S. K., Quinn, A. M., and Hunter, T. (1988). Science 241, 42-52.

    Google Scholar 

  • Herbert, E., Potter, V. R., and Takagi, Y. (1955). J. Biol. Chem. 213, 923-940.

    Google Scholar 

  • Howlett, A. R., Petersen, O. W., Steeg, P. S., and Bissell, M. J. (1994). J. Natl. Cancer Inst. 86, 1838-1844.

    Google Scholar 

  • Ishijima, Y., Shimada, N., Fukuda, M., Miyazaki, H., Orlov, N. Y. Orlova, T. G., Yamada, T., and Kimura, N. (1999). FEBS Lett. 445, 155-159.

    Google Scholar 

  • Izumiya, H., and Yamamoto, M. (1995). J. Biol. Chem. 270, 27859-27864.

    Google Scholar 

  • Jacobus, W. E., and Evans, J. J. (1977). J. Biol. Chem. 252, 4232-4241.

    Google Scholar 

  • Johnson, J. D., Mehus, J. G., Tews, K., Milavetz, B. I., and Lambeth, D. O. (1998a). J. Biol. Chem. 273, 27580-27586.

    Google Scholar 

  • Johnson, J. D., Muhonen, W. W., and Lambeth, D. O. (1998b). Biol. Chem. 273, 27573-27579.

    Google Scholar 

  • Keim, D., Hailat, N., Melhem, R., Zhu, X. X., Lascu, I., Veron, M., Strahler, J., and Hanash, S. M. (1992). J. Clin. Invest. 89, 919-924.

    Google Scholar 

  • Kimura, N. (1993). In Handbook of Experimental Pharmacology, Vol.108/II, Chap. 74. Springer-Verlag, Berlin, pp. 485-498.

  • Kimura, N., and Shimada, N. (1988). J. Biol. Chem. 263, 4647-4653.

    Google Scholar 

  • Kimura, N, Shimada, N., Nomura, K., and Watanabe, K. (1990). J. Biol. Chem. 265, 15744-15749.

    Google Scholar 

  • Kraeft, S. K., Traincart, F., Mesnildrey, S., Bourdais, J., Veron, M., and Chen, L. B. (1996). Exp. Cell Res. 227, 63-69.

    Google Scholar 

  • Krebs H. A., and Hems, R. (1953). Biochem. Biophys. Acta. 12, 172-180.

    Google Scholar 

  • Lacombe, M. L., Wallet, V., Troll, H., and Veron, M. (1990). J. Biol. Chem. 265, 10012-10018.

    Google Scholar 

  • Lakso, M., Steeg, P. S., and Westphal, H. (1992). Cell Growth Different. 3, 873-879.

    Google Scholar 

  • Lambeth, D. O., Frohlich, D. A., Kelly, J., and Adkins, S. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/ Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. P9.

  • Lambeth, D. O., Mehus, J. G., Ivey, M. A., and Milavetz, B. I. (1997). J. Biol. Chem. 272, 24604-24611.

    Google Scholar 

  • Lascu, I., Chaffotte, A., Limbourg-Bouchon, B., and Veron, M. (1992). J. Biol. Chem. 267, 12775-12781.

    Google Scholar 

  • Lee, H., Okada, K., Baba, H., Furukawa, K., Chang, S. I; and Shiku, H. (1997). Intern. J. Oncol. 11, 965-970.

    Google Scholar 

  • Leung, S. M., and Hightower, L. E. (1997). J. Biol. Chem. 272, 2607-2614.

    Google Scholar 

  • Levit, M. N., Postel, E. H., and Stock J. B. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T34

  • Lombardi, D., Lacombe, M. L., and Paggi, M. (2000). J. Cell Physiol. 182, 144-149.

    Google Scholar 

  • Lu, Q., Zhang, X., Almaula, N., Mathews, C. K., and Inouye, M. (1995) J. Mol. Biol. 254, 337-341.

    Google Scholar 

  • Martinez, R, Venturelli, D, Perrotti, D., Veronese, M. L., Kastury, K., Druck, T., Huebner, K., and Calabretta, B. (1997). Cancer Res. 57, 1180-1187.

    Google Scholar 

  • Marzo, I., Brenner, C., Zamzami, N., Jurgensmeier, J. M., Susin, S. A., Vieira, H. L, Prevost, M. C., Xie, Z., Matsuyama, S., Reed, J. C., and Kroemer, G. (1998). Science 281, 2027-2031.

    Google Scholar 

  • Mehus, J. G., Deloukas, P., and Lambeth, D. O. (1999). Human Genet. 104, 454-459.

    Google Scholar 

  • Mehus, J. G., and Lambeth, D. O (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T24.

  • Milon, L., Meyer, P., Chiadmi, M., Munier, A., Johansson, M., Karlsson, A., Lascu, I., Capeau, J., Janin, J., and Lacombe, M. L. (2000). J. Biol. Chem. 275, 14264-14272.

    Google Scholar 

  • Milon, L., Rousseau-Merck, M. F., Munier, A., Erent, M., Lascu, I., Capeau, J., and Lacombe, M. L. (1997). Human Genet. 99, 550-557.

    Google Scholar 

  • Min, K., Kim, S. Y., Song, H. K., Chang, C., Cho, S. J., Moon, J., Yang, J. K., Lee, J. Y., Lee, K. J. and Suh, S. W. (2000). Acta Crystallogr D56, 503-504

    Google Scholar 

  • Moréra, S., Lacombe, M. L., Xu, Y., LeBras, G., and Janin, J. (1995). Structure 3, 1307-1314.

    Google Scholar 

  • Muhonen, W. W., and Lambeth, D. O. (1995). Comp. Biochem. Physiol. B Biochem. Mol. Biol. 110, 211-23.

    Google Scholar 

  • Munier, A., Feral, C., Milon, L., Pinon, V. P., Gyapay, G., Capeau, J., Guellaen, G., and Lacombe, M. L. (1998). FEBS Lett. 434, 289-294.

    Google Scholar 

  • Munoz-Dorado, J., Inouye, M., and Inouye, S. (1990). J. Biol. Chem. 265, 2702-2706.

    Google Scholar 

  • Neupert, W. (1997). Annu. Rev. Biochem. 66, 863-917.

    Google Scholar 

  • Nickerson, J. A., and Wells, W. W. (1984). J. Biol. Chem. 259, 11297-11304.

    Google Scholar 

  • Ogawa, K., Takai, H., Ogiwara, A., Yokota, E., Shimizu, T., Inaba, K., and Mohri, H. (1996). Mol. Biol. Cell 7, 1895-1907.

    Google Scholar 

  • Okabe-Kado, J., Kasukabe, T., Hozumi, M., Honma, Y., Kimura, N., Baba, H., Urano, T., and Shiku, H. (1995). FEBS Lett 24, 311-315.

    Google Scholar 

  • Otero, A. de S. (1997). J. Biol. Chem. 275, 14690-14694.

    Google Scholar 

  • Ottaway, J. H., McClellan, J. A., and Saunderson, C. L. (1981). Intern. Biochem. 13, 401-410.

    Google Scholar 

  • Ouatas, T., Abdallah, B., Gasmi, L., Bourdais, J., Postel, E., and Mazabraud, A. (1997). Gene 194, 215-225.

    Google Scholar 

  • Pedersen, P. L. (1973). J. Biol. Chem. 248, 3956-3962.

    Google Scholar 

  • Pinon, V. P., Millot, G., Munier, A., Vassy, J., Linares-Cruz, G., Capeau, J., Calvo, F., and Lacombe, M. L. (1999). Exp. Cell Res. 246, 355-367.

    Google Scholar 

  • Prem veer Reddy, G., and Pardee, A. B. (1980). Proc. Natl. Acad. Sci. USA 77, 3312-3316.

    Google Scholar 

  • Ray, N. B., and Mathews, C. K. (1992). Current Topics Cell Reg. 33, 343-357.

    Google Scholar 

  • Reymond, A., Volorio, S., Merla, G., Al-Maghtheh, M., Zuffardi, O., Bulfone, A., Ballabio, A., and Zollo M. (1999). Oncogene 18, 7244-7252.

    Google Scholar 

  • Rosengard, A. M., Krutzsch, H. C., Shearn, A., Biggs, J. R., Barker, E., Margulies, I. M., King, C. R., Liotta, L. A., and Steeg, P. S. (1989). Nature (London) 342, 177-180.

    Google Scholar 

  • Sastre-Garau, X., Ovtracht, L., Lascu, I., Lacombe, M. L., Veron, M., Bourdache, K., and Thiery, J. P. (1992). Bull Cancer 79, 465-470.

    Google Scholar 

  • Schaertl, S., Geeves, M. A., and Konrad, M. (1999). J. Biol. Chem. 274, 20159-20164.

    Google Scholar 

  • Shimizu, S., Narita, M., and Tsujimoto, Y. (1999). Nature (London) 399, 483-487.

    Google Scholar 

  • Shingyoji, C., Higuchi, H., Yoshimura, M., Katayama, E., and Yanagida, T. (1998). Nature (London) 393, 711-714.

    Google Scholar 

  • Sonnemann, J., and Mutzel, R. (1995). Biochem. Biophys. Res. Commun. 209, 490-496.

    Google Scholar 

  • Stahl, J. A., Leone, A., Rosengard, A. M., Porter, L., King, C. R., and Steeg, P. S. (1991). Cancer Res. 51, 445-449.

    Google Scholar 

  • Steeg, P. S., Bevilacqua, G., Kopper, L., Thorgeirsson, U. P., Talmadge, J. E., Liotta, L. A., and Sobel, M. E. (1988). J. Natl. Cancer Inst. 80, 200-204.

    Google Scholar 

  • Traut, T. W. (1994). Mol. Cell Biochem. 140, 1-22.

    Google Scholar 

  • Troll, H., Winckler, T., Lascu, I., Muller, N., Saurin, W., Veron, M., and Mutzel, R. (1993). J. Biol. Chem. 268, 25469-25475.

    Google Scholar 

  • Tsuiki, H., Nitta, M., Furuya, A., Hanai, N., Fujiwara, T., Inagaki, M., Kochi, M., Ushio, Y., Saya, H., and Nakamura, H. (1999). J. Cell Biochem. 76, 254-269.

    Google Scholar 

  • Urano, T., Takamiya, K., Furukawa, K., and Shiku, H. (1992).. FEBS Lett. 309, 358-362.

    Google Scholar 

  • Varesco, L., Caligo, M. A., Simi, P., Black, D. M., Nardini, V., Casarino, L., Rocchi, M., Ferrara, G., Solomon, E., and Bevilacqua, G. (1992). Genes Chromosomes Cancer 4, 84-88.

    Google Scholar 

  • Venturelli, D., Martinez, R., Melotti, P., Casella, I., Peschle, C., Cucco, C., Spampinato, G., Darzynkiewicz, Z., and Calabretta, B. (1995). Proc. Natl. Acad. Sci. USA 92, 7435-7439.

    Google Scholar 

  • Wallet, V., Mutzel, R., Troll, H., Barzu, O., Wurster, B., Veron, M., and Lacombe, M. L. (1990). J. Natl. Cancer Inst. 82, 1199-1202.

    Google Scholar 

  • Wagner, P. D., and Vu, N. D. (2000). Biochem. J. 346, 623-630.

    Google Scholar 

  • Webb, P. A., Perisic, O., Mendola, C. E., Backer, J. M., and Williams, R. L. (1995). J. Mol. Biol. 251, 574-587.

    Google Scholar 

  • Willems, R., Van Bockstaele, D. R., Lardon, F., Lenjou, M., Nijs, G., Snoeck, H. W., Berneman, Z. N., and Slegers, H. (1998). J. Biol. Chem. 273, 13663-13668.

    Google Scholar 

  • Yamashiro, S., Urano, T., Shiku, H., and Furukawa, K. (1994). Oncogene 9, 2461-8.

    Google Scholar 

  • Yelick, P. C., Kwon, Y. H., Flynn, J. F., Borzorgzadeh, A., Kleene, K.C., and Hecht, N. B. (1989). Mol. Reprod. Develop. 1, 193-200.

    Google Scholar 

  • Zhang, X., Lu, Q., Inouye, M., and Mathews, C. K. (1996). J. Bacteriol. 178, 4115-4121.

    Google Scholar 

  • Zhu, J., Tseng, Y. H., Kantor, J. D., Rhodes, C. J., Zetter, B. R., Moyers, J. S., and Kahn, C. R. (1999). Proc. Natl. Acad. Sci. USA 96, 14911-14918.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculté de Médecine Saint-Antoine, INSERM U402, 75012, Paris, France

    Marie-Lise Laurence Lacombe

  2. Faculté de Médecine Saint-Antoine, INSERM U402, 75012, Paris, France

    Marie-Lise Laurence Lacombe & Annie Munier

  3. Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58202

    James G. Mehus

  4. Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58202

    David O. Lambeth

Authors
  1. Marie-Lise Laurence Lacombe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annie Munier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James G. Mehus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David O. Lambeth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lacombe, ML.L., Munier, A., Mehus, J.G. et al. The Human Nm23/Nucleoside Diphosphate Kinases. J Bioenerg Biomembr 32, 247–258 (2000). https://doi.org/10.1023/A:1005584929050

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1005584929050

Search

Navigation