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The Functional Role of β Subunits in Oligomeric P-Type ATPases

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Abstract

Na,K-ATPase and gastric and nongastric H,K-ATPases are the only P-type ATPases of higher organisms that are oligomeric and are associated with a β subunit, which is obligatory for expression and function of enzymes. Topogenesis studies suggest that β subunits have a fundamental and unique role in K+-transporting P-type ATPases in that they facilitate the correct membrane integration and packing of the catalytic α subunit of these P-type ATPases, which is necessary for their resistance to cellular degradation, their acquisition of functional properties, and their routing to the cell surface. In addition to this chaperone function, β subunits also participate in the determination of intrinsic transport properties of Na,K- and H,K-ATPases. Increasing experimental evidence suggests that β assembly is a highly ordered, β isoform-specific process, which is mediated by multiple interaction sites that contribute in a coordinate, multistep process to the structural and functional maturation of Na,K- and H,K-ATPases.

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Geering, K. The Functional Role of β Subunits in Oligomeric P-Type ATPases. J Bioenerg Biomembr 33, 425–438 (2001). https://doi.org/10.1023/A:1010623724749

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