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Participation of CaMKII in Neuronal Plasticity and Memory Formation

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Abstract

1. The unique biochemical properties of Ca2+/calmodulin (CaM)-dependent protein kinase II have made this enzyme one of the paradigmatic models of the forever searched “memory molecule.”

2. In particular, the central participation of CaMKII as a sensor of the Ca2+ signals generated by activation of NMDA receptors after the induction of long-term plastic changes, has encouraged the use of pharmacological, genetic, biochemical, and imaging tools to unveil the role of this kinase in the acquisition, consolidation, and expression of different types of memories.

3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity.

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Authors and Affiliations

  1. Departamento de Bioquímica, ICBS, UFRGS, Centro de Memória, Porto Alegre, Brasil

    Martín Cammarota, Lia R. M. Bevilaqua, Daniel S. Kerr, Bruno Reichmann, Viviane Teixeira, Mário Bulla & Iván Izquierdo

  2. Facultad de Medicina, UBA, Instituto de Biología Celular y Neurociencias “Prof. Dr. Eduardo de Robertis,”, Buenos Aires, Argentina

    Haydée Viola & Jorge H. Medina

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  1. Martín Cammarota
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  2. Lia R. M. Bevilaqua
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  3. Haydée Viola
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  4. Daniel S. Kerr
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  9. Jorge H. Medina
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Cammarota, M., Bevilaqua, L.R.M., Viola, H. et al. Participation of CaMKII in Neuronal Plasticity and Memory Formation. Cell Mol Neurobiol 22, 259–267 (2002). https://doi.org/10.1023/A:1020763716886

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