Abstract
DANTROLENE sodium or 1–[5–(p-nitrophenyl) furfurylidene amino] hydantoin sodium hydrate (DaNa) is a long-acting drug with skeletal muscle relaxant properties which has recently seemed clinically useful in the treatment of some types of muscle hypertonia1,2. DaNa does not affect neuromuscular transmission nor the electrical properties of skeletal muscle3 and it apparently involves the processes of excitation–contraction coupling1,3,4. The mode of action of DaNa has not been studied before on single muscle fibres and here we provide direct evidence that DaNa interferes with the intracellular movements of calcium ions.
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HAINAUT, K., DESMEDT, J. Effect of dantrolene sodium on calcium movements in single muscle fibres. Nature 252, 728–730 (1974). https://doi.org/10.1038/252728a0
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DOI: https://doi.org/10.1038/252728a0
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