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3′ Non-coding region sequences in eukaryotic messenger RNA

Nature volume 263, pages 211–214 (1976)Cite this article

Abstract

The sequence A–A–U–A–A–A is present in six different purified messenger RNA molecules (specifically the α- and β-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRN A of mouse (MOPC 21) and the ovalbumin mRN A of chicken) about 20 residues away from the 3′-terminal poly(A) sequence. In addition, a large selection of the 3′ non-coding regions of rabbit and human globin mRN As (both the α- and β- globin mRN As) are 85% homologous, demonstrating that this region is significantly conserved in evolution.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    N. J. Proudfoot & G. G. Brownlee

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  1. N. J. Proudfoot
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  2. G. G. Brownlee
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Proudfoot, N., Brownlee, G. 3′ Non-coding region sequences in eukaryotic messenger RNA. Nature 263, 211–214 (1976). https://doi.org/10.1038/263211a0

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