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Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes

Nature volume 311, pages 438–442 (1984)Cite this article

Abstract

Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells results in expression of c-fos mRNA and protein. This is accompanied by the appearance of morphologically altered cells which express several specific markers characteristic of differentiated cells, suggesting that c-fos plays a role in cellular differentiation.

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References

  1. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    Article  ADS  CAS  Google Scholar 

  2. Doolittle, R. F. et al. Science 221, 275–277 (1983).

    Article  ADS  CAS  Google Scholar 

  3. Downward, J. et al. Nature 307, 521–527 (1984).

    Article  ADS  CAS  Google Scholar 

  4. Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).

    Article  CAS  Google Scholar 

  5. Campisi, J., Gray, H. E., Pardee, A. B., Dean, M. & Sonenshein, G. E. Cell 36, 241–247 (1984).

    Article  CAS  Google Scholar 

  6. Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2194–2198.

  7. Müller, R., Slamon, D. J., Tremblay, J. M., Cline, M. J. & Verma, I. M. Nature 299, 640–644 (1982).

    Article  ADS  Google Scholar 

  8. Müller, R., Verma, I. M. & Adamson, E. D. EMBO J. 2, 679–684 (1983).

    Article  Google Scholar 

  9. Müller, R., Tremblay, J. M., Adamson, E. D. & Verma, I. M. Nature 304, 454–456 (1983).

    Article  ADS  Google Scholar 

  10. Müller, R., Müller, D. & Guilbert, L. EMBO J. 3, 1887–1890 (1984).

    Article  Google Scholar 

  11. Bernstine, E. G., Hooper, M. L., Grandchamp, S. & Ephrussi, B. Proc. natn. Acad. Sci. U.S.A. 70, 3899–3903 (1973).

    Article  ADS  CAS  Google Scholar 

  12. Mintz, B. & Fleischman, R. A. Adv. Cancer Res. 34, 221–278 (1981).

    Google Scholar 

  13. Wagner, E. F., Rüther, U. & Stewart, C. L. in The Impact of Gene Transfer Techniques in Eucaryotic Cell Biology (Springer, Berlin, in the press).

  14. Strickland, S. & Mahdavi, V. Cell 15, 393–403 (1978).

    Article  CAS  Google Scholar 

  15. Hogan, B. L. M., Taylor, A. & Adamson, E. Nature 291, 235–237 (1981).

    Article  ADS  CAS  Google Scholar 

  16. Liesi, P., Rechardt, L. & Wartiovaara, J. Nature 306, 265–267 (1983).

    Article  ADS  CAS  Google Scholar 

  17. Müller, R. Cold Spring Harb. Conf. Cell Prolif, 10, 451–468 (1983).

    Google Scholar 

  18. van Straaten, F., Müller, R., Curran, T., van Beveren, C. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).

    Article  ADS  CAS  Google Scholar 

  19. Van Beveren, C., van Straaten, F., Curran, T., Müller, R. & Verma, I. M. Cell 32, 1241–1255 (1983).

    Article  CAS  Google Scholar 

  20. Southern, P. J. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).

    CAS  Google Scholar 

  21. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  22. Curran, T. & Teich, N. M. J. Virol. 42, 114–122 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Curran, T., Miller, A. D., Zokas, F. L. & Verma, I. M. Cell 36, 259–268 (1984).

    Article  CAS  Google Scholar 

  24. Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).

    Article  CAS  Google Scholar 

  25. Boller, K. & Kemler, R. Cold Spring Harb. Conf. Cell Prolif. 10, 39–49 (1983).

    CAS  Google Scholar 

  26. Kahan, B. & Adamson, E. D. Cold Spring Harb. Conf. Cell Prolif. 10, 131–141 (1983).

    Google Scholar 

  27. Adamson, E. D., Gaunt, S. J. & Graham, C. F. Cell 17, 469–476 (1979).

    Article  CAS  Google Scholar 

  28. Waneck, G. L. & Rosenberg, N. Cell 26, 79–89 (1981).

    Article  CAS  Google Scholar 

  29. Witte, O. N. Curr. Topics Microbiol. Immun. 103, 127–146 (1983).

    CAS  Google Scholar 

  30. Rassoulzadegan, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4354–4358 (1983).

    Article  ADS  CAS  Google Scholar 

  31. Houweling, A., van der Elsen, P. & van der Eb., A. Virology 105, 537–550 (1980).

    Article  CAS  Google Scholar 

  32. Karin, M. et al. Nature 308, 513–519 (1984).

    Article  ADS  CAS  Google Scholar 

  33. Graham, F. L. & van der Eb, A. J. Virology 53, 456–467 (1973).

    Article  Google Scholar 

  34. Wagner, E. F. & Mintz, B. Molec. cell. Biol., 2, 190–198 (1982).

    Article  CAS  Google Scholar 

  35. Müller, R. et al. Molec. cell Biol. 3, 1062–1069 (1983).

    Article  Google Scholar 

  36. Curran, T., Peters, G., van Beveren, C., Teich, N. M. & Verma, I. M. J. Virol. 44, 674–682 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Lehrach, H., Diamond, D., Wozney, J. M. & Boedtcher, H. Biochemistry 16, 4743–4751 (1977).

    Article  CAS  Google Scholar 

  38. Adamson, E.D. & Grover, A. Cold Spring Harb. Conf. Cell Prolif. 10, 69–81 (1983).

    Google Scholar 

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Authors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10.2209, 6900, Heidelberg, FRG

    Rolf Müller & Erwin F. Wagner

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  1. Rolf Müller
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  2. Erwin F. Wagner
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Müller, R., Wagner, E. Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes. Nature 311, 438–442 (1984). https://doi.org/10.1038/311438a0

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