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Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Abstract

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.

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Leonard, W., Depper, J., Crabtree, G. et al. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311, 626–631 (1984). https://doi.org/10.1038/311626a0

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