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Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

Abstract

Cloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for inositol 1,4,5-triphosphate, a second messenger that mediates the release of intracellular calcium.

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References

  1. Mallet, J. et al. Brain Res. 103, 291–312 (1976).

    Article  CAS  Google Scholar 

  2. Mikoshiba, K. & Changeux, J.-P. Brain Res. 142, 487–504 (1978).

    Article  CAS  Google Scholar 

  3. Mikoshiba, K., Hutchet, M. & Changeux, J.-P. Devl Neurosci. 2, 254–275 (1979).

    Article  CAS  Google Scholar 

  4. Mikoshiba, K., Okano, H. & Tsukada, Y. Devl Neurosci. 7, 179–187 (1985).

    Article  CAS  Google Scholar 

  5. Yamamoto, H. et al. J. Neurochem. 53, 917–923 (1989).

    Article  CAS  Google Scholar 

  6. Maeda, N. et al. J. Neurochem. 51, 1724–1730 (1988).

    Article  CAS  Google Scholar 

  7. Maeda, N. Devl Biol. 133, 67–76 (1989).

    Article  CAS  Google Scholar 

  8. Berridge, M. J. A. Rev. Biochem. 56, 615–649 (1987).

    Article  Google Scholar 

  9. Supattapone, S. et al. J. Biol. Chem. 263, 1530–1534 (1988).

    CAS  PubMed  Google Scholar 

  10. Supattapone, S. et al. Proc. natn. Acad. Sci. U.S.A. 85, 8747–8750 (1988).

    Article  CAS  ADS  Google Scholar 

  11. Worley, P. F. et al. Nature 325, 159–161 (1987).

    Article  CAS  ADS  Google Scholar 

  12. Worley, P. F., Baraban, J. M. & Snyder, S. H. J. Neurosci. 9, 339–349 (1989).

    Article  CAS  Google Scholar 

  13. Groswald, D. E. & Kelly, P. T. J. Neurochem. 42, 534–546 (1984).

    Article  CAS  Google Scholar 

  14. Walaas, S. I., Nairn, A. C. & Greengard, P. J. Neurosci. 6, 954–961 (1986).

    Article  CAS  Google Scholar 

  15. Maeda, N., Niinobe, M. & Mikoshiba, K. EMBO J. (manuscript submitted).

  16. Furuichi, T., Yoshikawa, S. & Mikoshiba, K. Nucleic Acids Res. 17, 5385–5386 (1989).

    Article  CAS  Google Scholar 

  17. Takeshima, H. et al. Nature 339, 439–445 (1989).

    Article  CAS  ADS  Google Scholar 

  18. Kozak, M. Nucleic Acids Res. 12, 857–872 (1984).

    Article  CAS  Google Scholar 

  19. Tanabe, T. et al. Nature 328, 313–318 (1987).

    Article  CAS  ADS  Google Scholar 

  20. Klein, P., Kanehisa, M. & DeLisi, C. Biochim. biophys. Acta 815, 468–476 (1985).

    Article  CAS  Google Scholar 

  21. Hirano, A. & Dembitzer, H. M. J. Neuropathol. exp. Neurol. 34, 1–11 (1975).

    Article  CAS  Google Scholar 

  22. Mullen, R. J., Eicher, E. M. & Sidman, R. J. Proc. natn. Acad. Sci. U.S.A. 73, 208–212 (1976).

    Article  CAS  ADS  Google Scholar 

  23. Landis, S. J. Cell Biol. 57, 782–797 (1973).

    Article  CAS  Google Scholar 

  24. Rakic, P. & Sidman, R. L. J. Comp. Neurol. 152, 103–133 (1973).

    Article  CAS  Google Scholar 

  25. Higashida, H. & Brown, D. A. Nature 323, 333–335 (1986).

    Article  CAS  ADS  Google Scholar 

  26. Nordquist, D. T., Kozak, C. A. & Orr, H. T. J. Neurosci. 8, 4780–4789 (1989).

    Article  Google Scholar 

  27. Volpe, P. et al. Proc. natn. Acad. Sci. U.S.A. 85, 1091–1095 (1988).

    Article  CAS  ADS  Google Scholar 

  28. Hashimoto, S. et al. J. Cell Biol. 107, 2523–2531 (1988).

    Article  CAS  Google Scholar 

  29. Ross, C. A. et al. Nature 339, 468–470 (1989).

    Article  CAS  ADS  Google Scholar 

  30. Kuno, M. & Gardner, P. Nature 326, 301–304 (1987).

    Article  CAS  ADS  Google Scholar 

  31. Blackstone, C. D., Supattapone, S. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 86, 4316–4320 (1989).

    Article  CAS  ADS  Google Scholar 

  32. Crepel, F., Dupont, J.-L. & Gardette, R. J. Physiol., Lond. 346, 111–125 (1984).

    Article  CAS  Google Scholar 

  33. Perrett, C., Lomri, N. & Thomasset, M. J. molec. Evol. 27, 351–364 (1988).

    Article  ADS  Google Scholar 

  34. Brandl, C. J. et al. Cell 44, 597–607 (1986).

    Article  CAS  Google Scholar 

  35. Anderson, K. et al. J. biol. Chem. 264, 1329–1335 (1989).

    CAS  PubMed  Google Scholar 

  36. Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning, A Laboratory Manual (Cold Spring Harbor, New York, 1982).

    Google Scholar 

  37. Gubler, U. & Hoffman, B. J. Gene 25, 263–269 (1983).

    Article  CAS  Google Scholar 

  38. Huynh, T. V., Young, R. A. & Davis, R. W. in DNA Cloning, A Practical Approach Vol. 1 (ed. Glover, D. M.) 49–78 (IRL, Oxford, 1985).

    Google Scholar 

  39. Vieira, J. & Messing, J. in Methods in Enzymology, vol. 153 (eds Wu, R. & Gross) 3–11 (Academic Press, Inc. San Diego, 1987).

    Google Scholar 

  40. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  CAS  ADS  Google Scholar 

  41. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982).

    Article  CAS  Google Scholar 

  42. Shiota, C., Miura, M. & Mikoshiba, K. Devl Brain Res. 45, 83–94 (1989).

    Article  CAS  Google Scholar 

  43. Fregien, N. & Davidson, N. Gene 48, 1–11 (1986).

    Article  CAS  Google Scholar 

  44. Miura, M. et al. Gene 75, 31–38 (1989).

    Article  CAS  Google Scholar 

  45. Staden, R. Nucleic Acids Res. 10, 2951–2961 (1982).

    Article  CAS  Google Scholar 

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Furuichi, T., Yoshikawa, S., Miyawaki, A. et al. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature 342, 32–38 (1989). https://doi.org/10.1038/342032a0

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