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Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

Nature volume 342, pages 762–766 (1989)Cite this article

Abstract

The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photo-receptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes.

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Author information

Author notes

  1. Neil J. Cook

    Present address: Max-Planck-lnstitut für Biophysik, Abteilung Molekulare Membranbiologie, D-6000, Frankfurt, 71, FRG

  2. U. Benjamin Kaupp and Wolfgang Bönigk: Institut für Biologische Informationsverarbeitung, Kernforschungsanlage, D-5170 Jülich, FRG

  3. Walter Stühmer: Max-Planck-lnstitut für biophysikalische Chemie, D-3400 Göttingen, FRG

  4. Neil J. Cook: Abteilung Biophysik, Universität Osnabrück, D-4500 Osnabrück, FRG

  5. Kenji Kangawa and Hisayuki Matsuo: Department of Biochemistry, Miyazaki Medical College, Miyazaki 889-16, Japan

  6. Tadaaki Hirose: Pharmaceutical Institute, Keio University School of Medicine, Tokyo 160, Japan

  7. Takashi Miyata: Department of Biology, Kyushu University Faculty of Science, Fukuoka 812, Japan

Authors and Affiliations

  1. Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    U. Benjamin Kaupp, Tetsuhiro Niidome, Tsutomu Tanabe, Shoichi Terada, Wolfgang Bönigk, Walter Stühmer, Neil J. Cook, Kenji Kangawa, Hisayuki Matsuo, Tadaaki Hirose, Takashi Miyata & Shosaku Numa

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Kaupp, U., Niidome, T., Tanabe, T. et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342, 762–766 (1989). https://doi.org/10.1038/342762a0

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