Abstract
Cells display a remarkable ability to respond to small fluctuations in their surroundings. In simple microbial systems, information from sensory receptors feeds into a circuitry of regulatory proteins that transfer high energy phosphoryl groups from histidine to aspartate side chains. This phosphotransfer network couples environmental signals to an array of response elements that control cell motility and regulate gene expression.
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References
Kroger, M. Nature 339, 330 (1989).
Nikaido, H. & Vaara, M. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 7–22 (Am. Soc. Microbiol., Washington DC, 1987).
Csonka, L. N. Microbiol. Rev. 53, 121–147 (1989).
Forst, S. & Inouye, M. A. Rev. Cell Biol. 4, 21–42 (1988).
Igo, M. M., Ninfa, A. J. & Silhavy, T. J. Genes Dev. 3, 598–605 (1989).
Aiba, H., Mizuno, T. & Mizushima, S. J. biol. Chem. 264, 8563–8567 (1989).
Igo, M. M., Ninfa, A. J., Stock, J. B. & Silhavy, T. J. Genes Dev. 3, 1725–1734 (1989).
Aiba, H., Nakasai, F., Mizushima, S. & Mizuno, T. J. Biochem. (Tokyo) 106, 5–7 (1989).
Slauch, J. M. & Silhavy, T. J. J. molec. Biol. 210, 281–292 (1989).
Reitzer, L. J. & Magasanik, B. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 302–320 (Am. Soc. Microbiol., Washington DC, 1987).
Ninfa, A. J., Reitzer, L. J. & Magasanik, B. Cell 50, 1039–1046 (1987).
Chock, P. B., Shatter, E., Jurgensen, S. R. & Rhee, S. G. Curr. Top. Cell Regul. 27, 3–12 (1985).
Ninfa, A. J. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 83, 5909–5913 (1986).
Keener, J. & Kustu, S. Proc. natn. Acad. Sci. U.S.A. 85, 4976–4980 (1988).
Almassy, R. J., Janson, C. A., Hamlin, R., Xuong, N.-H. & Eisenberg, D. Nature 323, 304–309 (1986).
Weiss, V. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 85, 8919–8923 (1988).
Sundaresan, V., Ow, D. & Ausubel, F. M. Proc. natn. Acad. Sci. U.S.A. 80, 4030–4034 (1983).
Macnab, R. M. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 732–759 (Am. Soc. Microbiol., Washington, DC, 1987).
Stock, A., Chen, T., Welsh, D. & Stock, J. Proc. natn. Acad. Sci. U.S.A. 85, 1403–1407 (1988).
Koshland, D. E., Jr Biochemistry 27, 5829–5832 (1988).
Ames, P., Chen, J., Wolff, C. & Parkinson, J. S. Cold Spring Harbor Symp. quant. Biol. 53, 59–65 (1988).
Borkovich, K. A., Kaplan, N., Hess, J. F. & Simon, M. I. Proc. natn. Acad. Sci. U.S.A. 86, 1208–1212 (1989).
Stock, A. M., Koshland, D. E., Jr & Stock, J. B. Proc. natn. Acad. Sci. U.S.A. 82, 7989–7993 (1985).
Stock, A., Mottonen, J., Chen, T. & Stock, J. J. biol. Chem. 262, 535–537 (1987).
Wolfe, A. J., Conley, M. P., Kramer, T. J. & Berg, H. C. J. Bact. 169, 1878–1885 (1987).
Stock, A. M. et al. Cold Spring Harbor Symp. quant. Biol. 53, 49–57 (1988).
Hess, J. F., Bourret, R. B. & Simon, M. I. Nature 336, 139–143 (1988).
Sanders, D. A., Gilleve-Castro, B. L., Stock, A. M., Burlingame, A. L. & Koshland, D. E. Jr J. biol. Chem. 264, 21770–21778 (1989).
Hess, J. F., Oosawa, K., Kaplan, N. & Simon, M. I. Cell 53, 79–87 (1988).
Springer, M. S., Goy, M. F. & Adler, J. Nature 280, 279–284 (1979).
Stock, J. & Stock, A. Trends Biochem. Sci. 12, 371–375 (1987).
Lupas, A. N. & Stock, J. B. J. biol. Chem. 264, 17337–17342 (1989).
Simms, S. A., Keane, M. G. & Stock, J. J. biol. Chem. 260, 10161–10168 (1985).
Stewart, R. C. & Dahlquist, F. W. J. Bact. 170, 5728–5738 (1988).
Hazelbauer, G. L., Park, C. & Nowlin, D. M. Proc. natn. Acad. Sci. U.S.A. 86, 1448–1452 (1989).
Ninfa, A. J. et al. Proc. natn. Acad. Sci. U.S.A. 85, 5492–5496 (1988).
Stock, A. M., Mottonen, J. M., Stock, J. B. & Schutt, C. E. Nature 337, 745–749 (1989).
Branden, C.-I. Q. Rev. Biophys. 13, 317–338 (1980).
Yarden, Y. & Ullrich, A. A. Rev. Biochem. 57, 443–478 (1988).
Sprang, S. R. et al. Nature 336, 215–221 (1988).
Jencks, W. P. Adv. Enzym. 51, 75–106 (1980).
Tanford, C. CRC Crit. Rev. Biochem. 17, 123–152 (1984).
Shizuta, Y., Beavo, J. A., Bechtel, P. J., Hofmann, F. & Krebs, E. G. J. biol. Chem. 250, 6891–6896 (1975).
Fukami, Y. & Lipmann, F. Proc. natn. Acad. Sci. U.S.A. 80, 1872–1876 (1983).
Hubler, L., Gill, G. N. & Bertics, P. J. J. biol. Chem. 264, 1558–1564 (1989).
Wylie, D., Stock, A., Wong, C.-Y. & Stock, J. Biochem. biophys. Res. Commun. 151, 891–896 (1988).
Weigel, N., Kukuruzinska, M. A., Nakazawa, A., Waygood, E. B. & Roseman, S. J. biol. Chem. 257, 14477–14491 (1982).
Pickart, C. M. & Jencks, W. P. J. biol. Chem. 259, 1629–1643 (1984).
Jencks, W. P. in Handbook of Biochemistry (ed. Sober, H. A.) J144–J149 (CRC, Cleveland, 1968).
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Stock, J., Stock, A. & Mottonen, J. Signal transduction in bacteria. Nature 344, 395–400 (1990). https://doi.org/10.1038/344395a0
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DOI: https://doi.org/10.1038/344395a0
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